7SC5

Cytoplasmic tail deleted HIV Env trimer in nanodisc

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E	Envelope glycoprotein gp120	polymer	474	53092.1	3	UniProt (A0A6H1VID3) Pfam (PF00516) UniProt (by SIFTS) (Q2N0S6) In PDB	HIV whole-genome vector AA1305#18	Envelope glycoprotein gp160,Glycoprotein 120,Surface protein gp120,Transmembrane protein gp41
2	B, D, F	Transmembrane protein gp41	polymer	212	24114.8	3	UniProt (A0A173DX29) Pfam (PF00517) UniProt (by SIFTS) (Q2N0S6) In PDB	HIV whole-genome vector AA1305#18	Env polyprotein
3	G, I, J, L, M...	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	6	In PDB GlyTouCan (G15407YE)
4	H, K, N	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
5	B, C, D, E, A...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	36	Chemie (NAG)

Sequence modifications

A, C, E: 31 - 504 (UniProt: A0A6H1VID3)

PDB	External Database	Details
Arg 59	Lys 58	conflict
Ser 374	Tyr 373	conflict
Cys 499	Ala 498	conflict

B, D, F: 512 - 723 (UniProt: A0A173DX29)

PDB	External Database	Details
Pro 559	Ile 556	conflict
Cys 605	Thr 602	conflict
Glu 632	Asp 629	conflict
Leu 641	Ile 638	conflict
Thr 700	Ala 697	conflict
Ile 704	Val 701	conflict
Val 705	Ile 702	conflict
Asn 706	His 703	conflict
His 720	Leu 717	conflict
Ala 723	Thr 720	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	231620.5
Branched	Number of molecules	9
	Total formula weight	4792.5
Non-Polymers*	Number of molecules	36
	Total formula weight	7963.5
All*	Total formula weight	244376.5

*Water molecules are not included.