7SC3

CRYSTAL STRUCTURE OF THE N-DOMAIN OF CARDIAC MUSCLE TROPONIN C TETHERED TO THE SWITCH REGION OF CARDIAC MUSCLE TROPONIN I (ORTHORHOMBIC FORM)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle chimera	polymer	125	14186.1	1	UniProt (P63316) UniProt (P19429) Pfam (PF13833)	Homo sapiens (Human)	TN-C,Cardiac troponin I
2	B (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
3	C (A)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

A: 1 - 137 (UniProt: P63316)

PDB	External Database	Details
Ser 35	Cys 35	engineered mutation
Ser 84	Cys 84	engineered mutation

A: 138 - 163 (UniProt: P19429)

PDB	External Database	Details
Gly 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag
His 169	-	expression tag
His 170	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	14186.1
Non-Polymers*	Number of molecules	1
	Total formula weight	40.1
All*	Total formula weight	14226.2

*Water molecules are not included.