7SBF
PZM21 bound Mu Opioid Receptor-Gi Protein Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37671.1 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (E) | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus (Mouse) | ||
| 5 | E (R) | Soluble cytochrome b562, Mu-type opioid receptor chimera,Mu-type opioid receptor | polymer | 488 | 55123.8 | 1 | UniProt (P0ABE7) UniProt (P42866) Pfam (PF07361) Pfam (PF00001) | Escherichia coli | Cytochrome b-562,M-OR-1,MOR-1 |
| 6 | F (R) | N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea | non-polymer | 361.5 | 1 | Chemie (8QY) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: -52 - 52 (UniProt: P0ABE7)
R: 73 - 406 (UniProt: P42866)
| PDB | External Database | Details |
|---|---|---|
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys -73 | - | expression tag |
| Leu -72 | - | expression tag |
| Val -71 | - | expression tag |
| Phe -70 | - | expression tag |
| Ala -69 | - | expression tag |
| Asp -68 | - | expression tag |
| Tyr -67 | - | expression tag |
| Lys -66 | - | expression tag |
| Asp -65 | - | expression tag |
| Asp -64 | - | expression tag |
| Asp -63 | - | expression tag |
| Asp -62 | - | expression tag |
| Ala -61 | - | expression tag |
| Leu -60 | - | expression tag |
| Glu -59 | - | expression tag |
| Val -58 | - | expression tag |
| Leu -57 | - | expression tag |
| Phe -56 | - | expression tag |
| Gln -55 | - | expression tag |
| Gly -54 | - | expression tag |
| Pro -53 | - | expression tag |
| Trp -46 | Met 29 | conflict |
| Ile 49 | His 124 | conflict |
| Leu 53 | - | linker |
| Ala 54 | - | linker |
| Gly 55 | - | linker |
| Ser 56 | - | linker |
| Pro 57 | - | linker |
| Gly 58 | - | linker |
| Ala 59 | - | linker |
| Arg 60 | - | linker |
| Ser 61 | - | linker |
| Ala 62 | - | linker |
| Ser 63 | - | linker |
| Ser 64 | - | linker |
| Leu 65 | - | linker |
| Ala 66 | - | linker |
| Leu 67 | - | linker |
| Ala 68 | - | linker |
| Ile 69 | - | linker |
| Ala 70 | - | linker |
| Ile 71 | - | linker |
| Thr 72 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 359 | - | insertion |
| Glu 360 | - | insertion |
| Val 361 | - | insertion |
| Leu 362 | - | insertion |
| Phe 363 | - | insertion |
| Gln 364 | - | insertion |
| Gly 365 | - | insertion |
| Pro 366 | - | insertion |
| Asp 407 | - | expression tag |
| Ile 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| His 411 | - | expression tag |
| His 412 | - | expression tag |
| His 413 | - | expression tag |
| His 414 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 168856.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 361.5 | |
| All* | Total formula weight | 169217.5 |
