7SAN
Crystal structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 217 | 24385.0 | 4 | UniProt (P00492) Pfam (PF00156) | Homo sapiens (human) | HGPRT,HGPRTase |
| 2 | E, F, G, H (A, B, C, D) | ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid | non-polymer | 443.2 | 4 | Chemie (8QI) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 217 (UniProt: P00492)
| PDB | External Database | Details |
|---|---|---|
| Ala 22 | Cys 23 | engineered mutation |
| Ala 105 | Cys 106 | engineered mutation |
| Ala 205 | Cys 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97540.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1773.0 | |
| All* | Total formula weight | 99313.1 |
