7S5Q
Crystal structure of SARS-CoV-2 B.1.351 variant receptor binding domain in complex with neutralizing antibodies CS44 and COVA1-16
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Spike protein S1 | polymer | 231 | 26129.4 | 1 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | |
| 2 | B (B) | CS44 Heavy chain | polymer | 226 | 24008.0 | 1 | Homo sapiens (human) | ||
| 3 | C (C) | CS44 Light chain | polymer | 215 | 23447.0 | 1 | Homo sapiens (human) | ||
| 4 | D (H) | COVA1-16 Heavy chain | polymer | 232 | 25100.1 | 1 | Homo sapiens (human) | ||
| 5 | E (L) | COVA1-16 Light chain | polymer | 214 | 23415.8 | 1 | Homo sapiens (human) | ||
| 6 | F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | G, H, P, T, U (A, H, L) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 8 | I, J, K, L, M... (A, B, H, L) | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 9 | AA, W, X, Y, Z (L, A, B, C, H) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A: 319 - 541 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Asn 417 | Lys 417 | variant |
| Lys 484 | Glu 484 | variant |
| Tyr 501 | Asn 501 | variant |
| Ser 542 | - | expression tag |
| Gly 543 | - | expression tag |
| His 544 | - | expression tag |
| His 545 | - | expression tag |
| His 546 | - | expression tag |
| His 547 | - | expression tag |
| His 548 | - | expression tag |
| His 549 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 122100.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1588.2 | |
| All* | Total formula weight | 123688.4 |
