7S5P

Crystal structure of SARS-CoV-2 B.1.351 variant receptor binding domain in complex with neutralizing antibody CS23

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Spike protein S1	polymer	231	26129.4	1	UniProt (P0DTC2) Pfam (PF09408) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
2	H	CS23 Heavy chain	polymer	221	23244.1	1		Homo sapiens (human)
3	L	CS23 Light chain	polymer	213	22642.8	1		Homo sapiens (human)
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	A, H, L	SULFATE ION	non-polymer		96.1	13	Chemie (SO4)
6	H, L	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
7		water	water		18.0	29	Chemie (HOH)

Sequence modifications

A: 319 - 541 (UniProt: P0DTC2)

PDB	External Database	Details
Asn 417	Lys 417	variant
Lys 484	Glu 484	variant
Tyr 501	Asn 501	variant
Ser 542	-	expression tag
Gly 543	-	expression tag
His 544	-	expression tag
His 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	72016.3
Non-Polymers*	Number of molecules	16
	Total formula weight	1594.2
All*	Total formula weight	73610.5

*Water molecules are not included.