7S4C
Crystal Structure of Inhibitor-bound Galactokinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Galactokinase | polymer | 392 | 42203.0 | 2 | UniProt (P51570) Pfam (PF10509) Pfam (PF00288) Pfam (PF08544) | Homo sapiens (Human) | Galactose kinase |
| 2 | C, J (A, B) | alpha-D-galactopyranose | non-polymer | 180.2 | 2 | Chemie (GLA) | |||
| 3 | D, E, K (A, B) | 2-({(4R)-4-(2-chlorophenyl)-2-[(6-fluoro-1,3-benzoxazol-2-yl)amino]-6-methyl-1,4-dihydropyrimidine-5-carbonyl}amino)pyridine-4-carboxylic acid | non-polymer | 520.9 | 3 | Chemie (V3V) | |||
| 4 | F, L (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | G, H, I, M (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 6 | N, O (A, B) | water | water | 18.0 | 476 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 392 (UniProt: P51570)
| PDB | External Database | Details |
|---|---|---|
| Ala 252 | Lys 252 | engineered mutation |
| Ala 253 | Glu 253 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84406.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2348.9 | |
| All* | Total formula weight | 86754.9 |
