7S2S

nanobody bound to Interleukin-2Rbeta

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, A	IL2Rb-binding nanobody	polymer	154	16581.4	2		Camelus bactrianus
2	B, D	Interleukin-2 receptor subunit beta	polymer	216	25199.6	2	UniProt (P14784) Pfam (PF18707) In PDB	Homo sapiens (Human)	IL-2 receptor subunit beta,IL-2R subunit beta,IL-2RB,High affinity IL-2 receptor subunit beta,Interleukin-15 receptor subunit beta,p70-75,p75
3	E, F, H, I	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	4	In PDB GlyTouCan (G21290RB)
4	G, J	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	B, A, D	SULFATE ION	non-polymer		96.1	13	Chemie (SO4)
6		water	water		18.0	193	Chemie (HOH)

Sequence modifications

B, D: 27 - 236 (UniProt: P14784)

PDB	External Database	Details
His 237	-	expression tag
His 238	-	expression tag
His 239	-	expression tag
His 240	-	expression tag
His 241	-	expression tag
His 242	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	83561.9
Branched	Number of molecules	6
	Total formula weight	3455.3
Non-Polymers*	Number of molecules	13
	Total formula weight	1248.8
All*	Total formula weight	88266.0

*Water molecules are not included.