7S2R

nanobody bound to IL-2Rg

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cytokine receptor common subunit gamma	polymer	209	25124.0	1	UniProt (P31785) Pfam (PF22012) Pfam (PF21605) In PDB	Homo sapiens (Human)	Interleukin-2 receptor subunit gamma,IL-2 receptor subunit gamma,IL-2R subunit gamma,IL-2RG,gammaC,p64
2	B	nanobody gamma-nb6	polymer	159	17850.5	1		Camelus bactrianus
3	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	A, B	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
6	A, B	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
7		water	water		18.0	26	Chemie (HOH)

Sequence modifications

A: 55 - 254 (UniProt: P31785)

PDB	External Database	Details
Ala 52	-	cloning artifact
Asp 53	-	cloning artifact
Pro 54	-	cloning artifact
His 255	-	expression tag
His 256	-	expression tag
His 257	-	expression tag
His 258	-	expression tag
His 259	-	expression tag
His 260	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42974.5
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	16
	Total formula weight	1763.5
All*	Total formula weight	45162.3

*Water molecules are not included.