7S0Q

Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Insulin-like growth factor 1 receptor	polymer	952	108937.2	1	UniProt (P08069) Pfam (PF01030) Pfam (PF00757) In PDB	Homo sapiens (Human)	Insulin-like growth factor I receptor,IGF-I receptor
2	B	Insulin receptor	polymer	961	109809.6	1	UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) In PDB	Homo sapiens (Human)	IR
3	D	Insulin-like growth factor I	polymer	70	7663.8	1	UniProt (P05019) Pfam (PF00049) In PDB	Homo sapiens (Human)	IGF-I,Mechano growth factor,MGF,Somatomedin-C
4	C, F	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	A	beta-D-mannopyranose	non-polymer		180.2	1	Chemie (BMA)
7	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)

Sequence modifications

A: 1 - 905 (UniProt: P08069)

PDB	External Database	Details
Arg 906	-	expression tag
Met 907	-	expression tag
Lys 908	-	expression tag
Gln 909	-	expression tag
Leu 910	-	expression tag
Glu 911	-	expression tag
Asp 912	-	expression tag
Lys 913	-	expression tag
Val 914	-	expression tag
Glu 915	-	expression tag
Glu 916	-	expression tag
Leu 917	-	expression tag
Leu 918	-	expression tag
Ser 919	-	expression tag
Lys 920	-	expression tag
Asn 921	-	expression tag
Tyr 922	-	expression tag
His 923	-	expression tag
Leu 924	-	expression tag
Glu 925	-	expression tag
Asn 926	-	expression tag
Glu 927	-	expression tag
Val 928	-	expression tag
Ala 929	-	expression tag
Arg 930	-	expression tag
Leu 931	-	expression tag
Lys 932	-	expression tag
Lys 933	-	expression tag
Leu 934	-	expression tag
Val 935	-	expression tag
Gly 936	-	expression tag
Glu 937	-	expression tag
Arg 938	-	expression tag
Ser 939	-	expression tag
Ser 940	-	expression tag
Ser 941	-	expression tag
Glu 942	-	expression tag
Gln 943	-	expression tag
Lys 944	-	expression tag
Leu 945	-	expression tag
Ile 946	-	expression tag
Ser 947	-	expression tag
Glu 948	-	expression tag
Glu 949	-	expression tag
Asp 950	-	expression tag
Leu 951	-	expression tag
Asn 952	-	expression tag

B: 1 - 928 (UniProt: P06213)

PDB	External Database	Details
Arg 929	-	expression tag
Met 930	-	expression tag
Lys 931	-	expression tag
Gln 932	-	expression tag
Leu 933	-	expression tag
Glu 934	-	expression tag
Asp 935	-	expression tag
Lys 936	-	expression tag
Val 937	-	expression tag
Glu 938	-	expression tag
Glu 939	-	expression tag
Leu 940	-	expression tag
Leu 941	-	expression tag
Ser 942	-	expression tag
Lys 943	-	expression tag
Asn 944	-	expression tag
Tyr 945	-	expression tag
His 946	-	expression tag
Leu 947	-	expression tag
Glu 948	-	expression tag
Asn 949	-	expression tag
Glu 950	-	expression tag
Val 951	-	expression tag
Ala 952	-	expression tag
Arg 953	-	expression tag
Leu 954	-	expression tag
Lys 955	-	expression tag
Lys 956	-	expression tag
Leu 957	-	expression tag
Val 958	-	expression tag
Gly 959	-	expression tag
Glu 960	-	expression tag
Arg 961	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	226410.6
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	8
	Total formula weight	1728.6
All*	Total formula weight	229736.7

*Water molecules are not included.