7RXV

Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine, Malonate (MLA) and MgF3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	S-adenosylmethionine synthase isoform type-2	polymer	417	46279.4	1	UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773)	Homo sapiens (Human)	AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II
2	B (A)	5'-DEOXY-5'-METHYLTHIOADENOSINE	non-polymer		297.3	1	Chemie (MTA)
3	C (A)	ALANINE	non-polymer		89.1	1	Chemie (ALA)
4	D (A)	MALONIC ACID	non-polymer		104.1	1	Chemie (MLA)
5	E (A)	TRIFLUOROMAGNESATE	non-polymer		81.3	1	Chemie (MGF)
6	F (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
7	G (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
8	H (A)	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
9	I, J (A)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
10	K (A)	water	water		18.0	381	Chemie (HOH)

Sequence modifications

A: 1 - 395 (UniProt: P31153)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	46279.4
Non-Polymers*	Number of molecules	9
	Total formula weight	773.3
All*	Total formula weight	47052.6

*Water molecules are not included.