7RX8

Structure of METTL3-METTL14(R298H) mutant methyltransferase complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	N6-adenosine-methyltransferase 70 kDa subunit	polymer	225	25732.5	1	UniProt (Q86U44) Pfam (PF05063)	Homo sapiens (Human)	MT-A70,Methyltransferase-like protein 3
2	B (B)	N6-adenosine-methyltransferase non-catalytic subunit	polymer	349	39554.7	1	UniProt (Q9HCE5) Pfam (PF05063)	Homo sapiens (Human)	Methyltransferase-like protein 14,hMETTL14
3	C, D (A, B)	water	water		18.0	382	Chemie (HOH)

Sequence modifications

A: 357 - 580 (UniProt: Q86U44)

PDB	External Database	Details
Met 356	-	initiating methionine

B: 111 - 456 (UniProt: Q9HCE5)

PDB	External Database	Details
Gly 108	-	expression tag
Ser 109	-	expression tag
Gly 110	-	expression tag
His 298	Arg 298	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65287.2
All*	Total formula weight	65287.2

*Water molecules are not included.