7RWP
Crystal Structure of BPTF bromodomain in complex with 5-[4-(aminomethyl)anilino]-4-chloro-2-methylpyridazin-3(2H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nucleosome-remodeling factor subunit BPTF | polymer | 131 | 15408.4 | 1 | UniProt (Q12830) Pfam (PF00439) | Homo sapiens (Human) | Bromodomain and PHD finger-containing transcription factor,Fetal Alz-50 clone 1 protein,Fetal Alzheimer antigen |
| 2 | B (A) | 5-[4-(aminomethyl)anilino]-4-chloro-2-methylpyridazin-3(2H)-one | non-polymer | 264.7 | 1 | Chemie (7WZ) | |||
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D (A) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A: 2917 - 3037 (UniProt: Q12830)
| PDB | External Database | Details |
|---|---|---|
| Gly 2907 | - | expression tag |
| Thr 2908 | - | expression tag |
| Glu 2909 | - | expression tag |
| Asn 2910 | - | expression tag |
| Leu 2911 | - | expression tag |
| Tyr 2912 | - | expression tag |
| Phe 2913 | - | expression tag |
| Gln 2914 | - | expression tag |
| Ser 2915 | - | expression tag |
| Met 2916 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15408.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 304.8 | |
| All* | Total formula weight | 15713.2 |
