7RW7
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Compound 9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | S-adenosylmethionine synthase isoform type-2 | polymer | 396 | 43807.7 | 1 | UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) | Homo sapiens (Human) | AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II |
| 2 | B (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 3 | C, E (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | D, F, G, H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 5 | I (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | J (A) | (3'R)-2-[(cyclopropylmethyl)amino]-6-(4-methoxyphenyl)-1'-[(1H-pyrazol-5-yl)methyl]-5,6-dihydro-7H-spiro[pyrido[4,3-d]pyrimidine-8,3'-pyrrolidin]-7-one | non-polymer | 459.5 | 1 | Chemie (7UB) | |||
| 7 | K (A) | water | water | 18.0 | 778 | Chemie (HOH) |
Sequence modifications
A: 1 - 395 (UniProt: P31153)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43807.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1283.3 | |
| All* | Total formula weight | 45091.0 |
