7RW5
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | S-adenosylmethionine synthase isoform type-2 | polymer | 396 | 43807.7 | 4 | UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) | Homo sapiens (Human) | AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II |
| 2 | E, G (B, D) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 3 | F (B) | (3'R)-N-(cyclopropylmethyl)-1'-[(2-fluorophenyl)methyl]-4-methyl-5H,7H-spiro[pyrano[4,3-d]pyrimidine-8,3'-pyrrolidin]-2-amine | non-polymer | 382.5 | 1 | Chemie (7U2) | |||
| 4 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 459 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 395 (UniProt: P31153)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 175230.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1179.3 | |
| All* | Total formula weight | 176410.2 |
