7RTK
Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cysteine desulfurase, mitochondrial | polymer | 406 | 45081.6 | 1 | UniProt (Q9Y697) Pfam (PF00266) In PDB | Homo sapiens (Human) | |
| 2 | B | LYR motif-containing protein 4 | polymer | 91 | 10763.5 | 1 | UniProt (Q9HD34) Pfam (PF05347) In PDB | Homo sapiens (Human) | |
| 3 | C | Acyl carrier protein | polymer | 77 | 8514.3 | 1 | UniProt (B7MJ81) Pfam (PF00550) UniProt (by SIFTS) (P0A6A8) In PDB | Escherichia coli | ACP |
| 4 | D | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial | polymer | 143 | 15636.0 | 1 | UniProt (Q9H1K1) Pfam (PF01592) In PDB | Homo sapiens (Human) | NifU-like N-terminal domain-containing protein,NifU-like protein |
| 5 | A | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 1 | Chemie (PLP) | |||
| 6 | D, A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 29 | Chemie (EDO) | |||
| 7 | D, A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 8 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 9 | A, B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 8 | Chemie (PEG) | |||
| 10 | A | 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL | non-polymer | 296.4 | 1 | Chemie (P15) | |||
| 11 | A | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 12 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 13 | B | {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID | non-polymer | 292.2 | 1 | Chemie (EDT) | |||
| 14 | C | S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate | non-polymer | 540.7 | 1 | Chemie (8Q1) | |||
| 15 | C | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 16 | D | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 17 | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 56 - 457 (UniProt: Q9Y697)
B: 1 - 91 (UniProt: Q9HD34)
D: 35 - 167 (UniProt: Q9H1K1)
| PDB | External Database | Details |
|---|---|---|
| Met 52 | - | initiating methionine |
| Gly 53 | - | expression tag |
| Ser 54 | - | expression tag |
| Ser 55 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 11 | Ser 11 | variant |
| PDB | External Database | Details |
|---|---|---|
| Met 33 | - | initiating methionine |
| Ala 34 | - | expression tag |
| Asp 35 | Tyr 35 | conflict |
| Leu 168 | - | expression tag |
| Glu 169 | - | expression tag |
| His 170 | - | expression tag |
| His 171 | - | expression tag |
| His 172 | - | expression tag |
| His 173 | - | expression tag |
| His 174 | - | expression tag |
| His 175 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 79995.4 | |
| Non-Polymers* | Number of molecules | 51 |
| Total formula weight | 5534.1 | |
| All* | Total formula weight | 85529.5 |
