7RTB
Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45683.4 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (N) | Nb35 | polymer | 128 | 13885.4 | 1 | Lama glama | ||
| 5 | E (R) | Glucagon-like peptide 1 receptor | polymer | 490 | 56668.3 | 1 | UniProt (P43220) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (Human) | GLP-1 receptor,GLP-1-R,GLP-1R |
| 6 | F (P) | Peptide-19 | polymer | 38 | 4093.5 | 1 | synthetic construct | ||
| 7 | G (R) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
R: 22 - 463 (UniProt: P43220)
| PDB | External Database | Details |
|---|---|---|
| Asn 54 | Ser 54 | conflict |
| Ala 226 | Gly 226 | conflict |
| Ala 268 | Glu 268 | conflict |
| Lys 271 | Asn 271 | conflict |
| Asp 274 | Lys 274 | conflict |
| Lys 280 | Arg 280 | conflict |
| Asp 284 | Thr 284 | conflict |
| Thr 285 | Ile 285 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| Lys -6 | - | expression tag |
| Thr -5 | - | expression tag |
| Ile -4 | - | expression tag |
| Ile -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Tyr 1 | - | expression tag |
| Ile 2 | - | expression tag |
| Phe 3 | - | expression tag |
| Cys 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Val 6 | - | expression tag |
| Phe 7 | - | expression tag |
| Ala 8 | - | expression tag |
| Asp 9 | - | expression tag |
| Tyr 10 | - | expression tag |
| Lys 11 | - | expression tag |
| Asp 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Asp 14 | - | expression tag |
| Asp 15 | - | expression tag |
| Leu 16 | - | expression tag |
| Glu 17 | - | expression tag |
| Val 18 | - | expression tag |
| Leu 19 | - | expression tag |
| Phe 20 | - | expression tag |
| Gln 21 | - | expression tag |
| Phe 260 | Leu 260 | variant |
| His 381 | Phe 381 | conflict |
| Pro 464 | - | expression tag |
| Ala 465 | - | expression tag |
| Gly 466 | - | expression tag |
| Leu 467 | - | expression tag |
| Glu 468 | - | expression tag |
| Val 469 | - | expression tag |
| Leu 470 | - | expression tag |
| Phe 471 | - | expression tag |
| Gln 472 | - | expression tag |
| Gly 473 | - | expression tag |
| Pro 474 | - | expression tag |
| His 475 | - | expression tag |
| His 476 | - | expression tag |
| His 477 | - | expression tag |
| His 478 | - | expression tag |
| His 479 | - | expression tag |
| His 480 | - | expression tag |
| His 481 | - | expression tag |
| His 482 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 163991.8 | |
| All* | Total formula weight | 163991.8 |
