7RSV

Structure of the VPS34 kinase domain with compound 5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Phosphatidylinositol 3-kinase catalytic subunit type 3	polymer	612	70075.9	2	UniProt (Q8NEB9) Pfam (PF00613) Pfam (PF00454)	Homo sapiens (Human)	PI3-kinase type 3,PI3K type 3,PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34
2	C, J (A, B)	(5aS,8aR,9S)-2-[(3R)-3-methylmorpholin-4-yl]-5,5a,6,7,8,8a-hexahydro-4H-cyclopenta[e]pyrazolo[1,5-a]pyrazin-4-one	non-polymer		276.3	2	Chemie (7IQ)
3	D, E, K (A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
4	F, G, H, I, L (A, B)	SODIUM ION	non-polymer		23.0	5	Chemie (NA)
5	M, N (A, B)	water	water		18.0	836	Chemie (HOH)

Sequence modifications

A, B: 282 - 879 (UniProt: Q8NEB9)

PDB	External Database	Details
His 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag
His 271	-	expression tag
His 272	-	expression tag
His 273	-	expression tag
Gly 274	-	expression tag
Glu 275	-	expression tag
Asn 276	-	expression tag
Leu 277	-	expression tag
Tyr 278	-	expression tag
Phe 279	-	expression tag
Gln 280	-	expression tag
Gly 281	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140151.9
Non-Polymers*	Number of molecules	10
	Total formula weight	943.9
All*	Total formula weight	141095.8

*Water molecules are not included.