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7RS4

Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-8

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DEstrogen receptorpolymer25729380.54UniProt (P03372)
Pfam (PF00104)
In PDB
Homo sapiens (Human)ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2A, B, C, D(2E)-3-{4-[(1E)-2-(2-chloro-4-fluorophenyl)-1-(2H-indazol-5-yl)but-1-en-1-yl]phenyl}prop-2-enoic acidnon-polymer446.94Chemie (7I0)
3B, DCHLORIDE IONnon-polymer35.52Chemie (CL)
4waterwater18.0205Chemie (HOH)
Sequence modifications
A, B, C, D: 298 - 554 (UniProt: P03372)
PDBExternal DatabaseDetails
Ser 372Leu 372engineered mutation
Ser 536Leu 536engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight117522.1
Non-Polymers*Number of molecules6
Total formula weight1858.5
All*Total formula weight119380.6
*Water molecules are not included.

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PDB entries from 2024-06-12

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