7RS2
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-23
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Estrogen receptor | polymer | 260 | 29709.8 | 4 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | E, F, G, H (A, B, C, D) | (2E)-3-(4-{[(1S,2R,4S,5S,6S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]heptane-2-sulfonyl](2,2,2-trifluoroethyl)amino}phenyl)prop-2-enoic acid | non-polymer | 587.6 | 4 | Chemie (7I5) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 345 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 295 | - | expression tag |
| Asn 296 | - | expression tag |
| Ala 297 | - | expression tag |
| Ser 372 | Leu 372 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 118839.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2350.3 | |
| All* | Total formula weight | 121189.6 |
