7RQZ

Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, C, B, D)	Transient receptor potential cation channel subfamily V member 1	polymer	868	98719.8	4	UniProt (O35433) Pfam (PF00023) Pfam (PF00520)	Rattus norvegicus (Rat)	TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like
2	E, J, O, U (A, C, B, D)	resiniferatoxin	non-polymer		628.7	4	Chemie (6EU)
3	F, I, K, N, P... (A, C, B, D)	1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine	non-polymer		760.1	8	Chemie (LBN)
4	G, H, L, M, Q... (A, C, B, D)	[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate	non-polymer		718.0	8	Chemie (6OU)

Sequence modifications

A, C, B, D: 1 - 838 (UniProt: O35433)

PDB	External Database	Details
Glu 839	-	expression tag
Asn 840	-	expression tag
Ser 841	-	expression tag
Leu 842	-	expression tag
Glu 843	-	expression tag
Val 844	-	expression tag
Leu 845	-	expression tag
Phe 846	-	expression tag
Gln 847	-	expression tag
Gly 848	-	expression tag
Pro 849	-	expression tag
Asp 850	-	expression tag
Tyr 851	-	expression tag
Lys 852	-	expression tag
Asp 853	-	expression tag
Asp 854	-	expression tag
Asp 855	-	expression tag
Asp 856	-	expression tag
Lys 857	-	expression tag
Ala 858	-	expression tag
His 859	-	expression tag
His 860	-	expression tag
His 861	-	expression tag
His 862	-	expression tag
His 863	-	expression tag
His 864	-	expression tag
His 865	-	expression tag
His 866	-	expression tag
His 867	-	expression tag
His 868	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	394879.0
Non-Polymers*	Number of molecules	20
	Total formula weight	14339.4
All*	Total formula weight	409218.4

*Water molecules are not included.