7RQZ
Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, C, B, D) | Transient receptor potential cation channel subfamily V member 1 | polymer | 868 | 98719.8 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) | Rattus norvegicus (Rat) | TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like |
| 2 | E, J, O, U (A, C, B, D) | resiniferatoxin | non-polymer | 628.7 | 4 | Chemie (6EU) PubChem (5311411) PubChem (5702546) PubChem (6324660) PubChem (44564218) PubChem (2733497) PubChem (176519982) PubChem (104826) PubChem (71718531) PubChem (5148108) PubChem (117893115) PubChem (53776296) PubChem (124525003) PubChem (57090162) PubChem (134688669) PubChem (15814491) PubChem (171342682) PubChem (92845090) PubChem (137635852) PubChem (139248250) | |||
| 3 | F, I, K, N, P... (A, C, B, D) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | non-polymer | 760.1 | 8 | Chemie (LBN) | |||
| 4 | G, H, L, M, Q... (A, C, B, D) | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | non-polymer | 718.0 | 8 | Chemie (6OU) PubChem (3246975) PubChem (5282290) PubChem (5283496) PubChem (5785226) PubChem (23727968) PubChem (123931) PubChem (90470676) PubChem (92863393) |
Sequence modifications
A, C, B, D: 1 - 838 (UniProt: O35433)
| PDB | External Database | Details |
|---|---|---|
| Glu 839 | - | expression tag |
| Asn 840 | - | expression tag |
| Ser 841 | - | expression tag |
| Leu 842 | - | expression tag |
| Glu 843 | - | expression tag |
| Val 844 | - | expression tag |
| Leu 845 | - | expression tag |
| Phe 846 | - | expression tag |
| Gln 847 | - | expression tag |
| Gly 848 | - | expression tag |
| Pro 849 | - | expression tag |
| Asp 850 | - | expression tag |
| Tyr 851 | - | expression tag |
| Lys 852 | - | expression tag |
| Asp 853 | - | expression tag |
| Asp 854 | - | expression tag |
| Asp 855 | - | expression tag |
| Asp 856 | - | expression tag |
| Lys 857 | - | expression tag |
| Ala 858 | - | expression tag |
| His 859 | - | expression tag |
| His 860 | - | expression tag |
| His 861 | - | expression tag |
| His 862 | - | expression tag |
| His 863 | - | expression tag |
| His 864 | - | expression tag |
| His 865 | - | expression tag |
| His 866 | - | expression tag |
| His 867 | - | expression tag |
| His 868 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 394879.0 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 14339.4 | |
| All* | Total formula weight | 409218.4 |
