7RP3
Crystal structure of GNE-1952 alkylated KRAS G12C in complex with 2H11 CLAMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2B of GTPase KRas | polymer | 171 | 19417.9 | 1 | UniProt (P01116-2) Pfam (PF00071) UniProt (by SIFTS) (P01116) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B (H) | immunoglobulin IgG heavy chain | polymer | 226 | 23833.6 | 1 | Homo sapiens (Human) | ||
| 3 | C (I) | immunoglobulin IgG light chain | polymer | 215 | 22878.3 | 1 | Homo sapiens (Human) | ||
| 4 | D (A) | 1-[4-[6-chloranyl-7-(5-methyl-1~{H}-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl]propan-1-one | non-polymer | 434.9 | 1 | Chemie (MKZ) | |||
| 5 | E (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 6 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | G, H, I, N (A, I) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 8 | J, K, M (H, I) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 9 | L (I) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 10 | O, P, Q (A, H, I) | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence modifications
A: 2 - 169 (UniProt: P01116-2)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 66129.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1553.1 | |
| All* | Total formula weight | 67682.8 |
