7RP2
Crystal structure of Kas G12C in complex with 2H11 CLAMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTPase KRas | polymer | 170 | 19352.8 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B (H) | immunoglobulin IgG heavy chain | polymer | 226 | 23833.6 | 1 | Homo sapiens (Human) | ||
| 3 | C (I) | immunoglobulin IgG light chain | polymer | 215 | 22878.3 | 1 | Homo sapiens (Human) | ||
| 4 | D (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F, H, I (H, I) | CACODYLATE ION | non-polymer | 137.0 | 3 | Chemie (CAC) | |||
| 7 | G (H) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 8 | J, K, L (A, H, I) | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
| Ser 51 | Cys 51 | engineered mutation |
| Leu 80 | Cys 80 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 66064.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 940.5 | |
| All* | Total formula weight | 67005.2 |
