7ROT
Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine--tRNA ligase | polymer | 373 | 43456.1 | 2 | UniProt (Q8IAR7) Pfam (PF00579) | Plasmodium falciparum (isolate 3D7) | |
| 2 | C, G (A, B) | {(2R,3S,4R,5R)-5-[4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl}methyl [(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfamate (non-preferred name) | non-polymer | 575.5 | 2 | Chemie (66I) | |||
| 3 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 373 (UniProt: Q8IAR7)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Cys 234 | Ser 234 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86912.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1235.1 | |
| All* | Total formula weight | 88147.4 |
