7RN6
High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to type-II inhibitor BBT594
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase JAK2 | polymer | 298 | 35001.9 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
2 | A | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1H-indole-1-carboxamide | non-polymer | 569.6 | 1 | Chemie (046) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
4 | water | water | 18.0 | 203 | Chemie (HOH) |
Sequence modifications
A: 839 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Gly 835 | - | expression tag |
Ala 836 | - | expression tag |
Phe 837 | - | expression tag |
Ala 838 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35001.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 631.6 | |
All* | Total formula weight | 35633.6 |