7RJ9

Crystal structure of the Vitronectin hemopexin-like domain binding Calcium

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Vitronectin	polymer	204	23436.2	2	UniProt (P04004) Pfam (PF00045) In PDB	Homo sapiens (Human)	VN,S-protein,Serum-spreading factor,V75
2	A, B	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
3	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	A, B	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
5	B	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6		water	water		18.0	344	Chemie (HOH)

Sequence modifications

A, B: 154 - 474 (UniProt: P04004)

PDB	External Database	Details
Met 153	-	initiating methionine
Ser 180	Cys 180	engineered mutation
Ser 215	Cys 215	engineered mutation
-	His 286	deletion
-	Gln 287	deletion
-	Pro 288	deletion
-	Ser 289	deletion
-	Gln 290	deletion
-	Glu 291	deletion
-	Glu 292	deletion
-	Cys 293	deletion
-	Glu 294	deletion
-	Gly 295	deletion
-	Ser 296	deletion
-	Ser 297	deletion
-	Leu 298	deletion
-	Ser 299	deletion
-	Ala 300	deletion
-	Val 301	deletion
-	Phe 302	deletion
-	Glu 303	deletion
-	His 304	deletion
-	Phe 305	deletion
-	Ala 306	deletion
-	Met 307	deletion
-	Met 308	deletion
-	Gln 309	deletion
-	Arg 310	deletion
-	Asp 311	deletion
-	Ser 312	deletion
-	Trp 313	deletion
-	Glu 314	deletion
-	Asp 315	deletion
-	Ile 316	deletion
-	Phe 317	deletion
-	Glu 318	deletion
-	Leu 319	deletion
-	Leu 320	deletion
-	Phe 321	deletion
-	Trp 322	deletion
-	Gly 323	deletion
-	Tyr 355	deletion
-	Ile 356	deletion
-	Ser 357	deletion
-	Gly 358	deletion
-	Met 359	deletion
-	Ala 360	deletion
-	Pro 361	deletion
-	Arg 362	deletion
-	Pro 363	deletion
-	Ser 364	deletion
-	Leu 365	deletion
-	Ala 366	deletion
-	Lys 367	deletion
-	Lys 368	deletion
-	Gln 369	deletion
-	Arg 370	deletion
-	Phe 371	deletion
-	Arg 372	deletion
-	His 373	deletion
-	Arg 374	deletion
-	Asn 375	deletion
-	Arg 376	deletion
-	Lys 377	deletion
-	Gly 378	deletion
-	Tyr 379	deletion
-	Arg 380	deletion
-	Ser 381	deletion
-	Gln 382	deletion
-	Arg 383	deletion
-	Gly 384	deletion
-	His 385	deletion
-	Ser 386	deletion
-	Arg 387	deletion
-	Gly 388	deletion
-	Arg 389	deletion
-	Asn 390	deletion
-	Gln 391	deletion
-	Asn 392	deletion
-	Ser 393	deletion
-	Arg 394	deletion
-	Arg 395	deletion
-	Pro 396	deletion
-	Ser 397	deletion
-	Arg 398	deletion
-	Ala 399	deletion
-	Thr 400	deletion
-	Trp 401	deletion
-	Leu 402	deletion
-	Ser 403	deletion
-	Leu 404	deletion
-	Phe 405	deletion
-	Ser 406	deletion
-	Ser 407	deletion
-	Glu 408	deletion
-	Glu 409	deletion
-	Ser 410	deletion
-	Asn 411	deletion
-	Leu 412	deletion
-	Gly 413	deletion
-	Ala 414	deletion
-	Asn 415	deletion
-	Asn 416	deletion
-	Tyr 417	deletion
-	Asp 418	deletion
-	Asp 419	deletion
-	Tyr 420	deletion
-	Arg 421	deletion
-	Met 422	deletion
-	Asp 423	deletion
-	Trp 424	deletion
-	Leu 425	deletion
-	Val 426	deletion
-	Pro 427	deletion
-	Ala 428	deletion
-	Thr 429	deletion
-	Cys 430	deletion
-	Glu 431	deletion
-	Pro 432	deletion
-	Ile 433	deletion
-	Gln 434	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	46872.4
Non-Polymers*	Number of molecules	7
	Total formula weight	293.1
All*	Total formula weight	47165.5

*Water molecules are not included.