7RHS
Cryo-EM structure of apo-state of human CNGA3/CNGB3 channel
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Cyclic nucleotide-gated cation channel alpha-3 | polymer | 706 | 80233.2 | 3 | UniProt (Q16281) Pfam (PF00520) Pfam (PF00027) Pfam (PF16526) In PDB | Homo sapiens (Human) | Cone photoreceptor cGMP-gated channel subunit alpha,Cyclic nucleotide-gated channel alpha-3,CNG channel alpha-3,CNG-3,CNG3 |
| 2 | D | Cyclic nucleotide-gated cation channel beta-3 | polymer | 841 | 95450.8 | 1 | UniProt (Q9NQW8) Pfam (PF00520) Pfam (PF00027) In PDB | Homo sapiens (Human) | Cone photoreceptor cGMP-gated channel subunit beta,Cyclic nucleotide-gated cation channel modulatory subunit,Cyclic nucleotide-gated channel beta-3,CNG channel beta-3 |
| 3 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 4 | D | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) |
Sequence modifications
A, B, C: 1 - 694 (UniProt: Q16281)
D: 2 - 809 (UniProt: Q9NQW8)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asp 695 | - | expression tag |
| Tyr 696 | - | expression tag |
| Lys 697 | - | expression tag |
| Asp 698 | - | expression tag |
| Asp 699 | - | expression tag |
| Asp 700 | - | expression tag |
| Asp 701 | - | expression tag |
| Lys 702 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -31 | - | initiating methionine |
| Gly -30 | - | expression tag |
| Ser -29 | - | expression tag |
| Trp -28 | - | expression tag |
| Ser -27 | - | expression tag |
| His -26 | - | expression tag |
| Pro -25 | - | expression tag |
| Gln -24 | - | expression tag |
| Phe -23 | - | expression tag |
| Glu -22 | - | expression tag |
| Lys -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Gly -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Ser -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ala -9 | - | expression tag |
| Trp -8 | - | expression tag |
| Ser -7 | - | expression tag |
| His -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Glu -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 336150.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 686.6 | |
| All* | Total formula weight | 336837.0 |
