7RHJ
Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-blocked open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, D (A, C, D) | cGMP-gated cation channel alpha-1 | polymer | 560 | 64650.4 | 3 | UniProt (P29973) Pfam (PF00520) Pfam (PF00027) Pfam (PF16526) | Homo sapiens (Human) | Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,CNG1,Cyclic nucleotide-gated channel,photoreceptor,Rod photoreceptor cGMP-gated channel subunit alpha |
| 2 | B (B) | Cyclic nucleotide-gated cation channel beta-1 | polymer | 810 | 91039.3 | 1 | UniProt (Q14028) Pfam (PF00520) Pfam (PF00027) | Homo sapiens (Human) | Cyclic nucleotide-gated cation channel 4,CNG channel 4,CNG-4,CNG4,Cyclic nucleotide-gated cation channel gamma,Cyclic nucleotide-gated cation channel modulatory subunit,Cyclic nucleotide-gated channel beta-1,CNG channel beta-1,Glutamic acid-rich protein,GARP |
| 3 | E, F, G, I (A, B, C, D) | CYCLIC GUANOSINE MONOPHOSPHATE | non-polymer | 345.2 | 4 | Chemie (PCG) PubChem (177270406) PubChem (136759845) PubChem (135398570) PubChem (135402012) PubChem (135415582) PubChem (135530416) PubChem (135566687) PubChem (135612771) PubChem (136122637) PubChem (136183234) PubChem (136183235) PubChem (136239427) PubChem (136268916) PubChem (136454903) PubChem (136454906) PubChem (136488083) PubChem (136488088) PubChem (136499047) PubChem (136678837) PubChem (137218937) PubChem (137234705) PubChem (137279777) PubChem (138399475) PubChem (164162904) | |||
| 4 | H (D) | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate | non-polymer | 414.5 | 1 | Chemie (5H0) |
Sequence modifications
A, C, D: 144 - 690 (UniProt: P29973)
B: 454 - 1251 (UniProt: Q14028)
| PDB | External Database | Details |
|---|---|---|
| Met 131 | - | expression tag |
| Asp 132 | - | expression tag |
| Tyr 133 | - | expression tag |
| Lys 134 | - | expression tag |
| Asp 135 | - | expression tag |
| Asp 136 | - | expression tag |
| Asp 137 | - | expression tag |
| Asp 138 | - | expression tag |
| Lys 139 | - | expression tag |
| Gly 140 | - | expression tag |
| Gly 141 | - | expression tag |
| Ser 142 | - | expression tag |
| Ala 143 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 442 | - | expression tag |
| Asp 443 | - | expression tag |
| Tyr 444 | - | expression tag |
| Lys 445 | - | expression tag |
| Asp 446 | - | expression tag |
| Asp 447 | - | expression tag |
| Asp 448 | - | expression tag |
| Asp 449 | - | expression tag |
| Lys 450 | - | expression tag |
| Gly 451 | - | expression tag |
| Gly 452 | - | expression tag |
| Ser 453 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 284990.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1795.3 | |
| All* | Total formula weight | 286785.9 |
