7RGQ

HUMAN RETINAL VARIANT IMPDH1(546) TREATED WITH GTP, ATP, IMP, NAD+; INTERFACE-CENTERED

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Inosine-5'-monophosphate dehydrogenase 1	polymer	546	58370.8	8	UniProt (P20839) Pfam (PF00478) Pfam (PF00571) In PDB	Homo sapiens (Human)	IMP dehydrogenase 1,IMPD 1,IMPDH 1,IMPDH-I
2	D, E, F, A, G...	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	16	Chemie (GTP)
3	E, F, A, G, B...	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	8	Chemie (NAD)
4	E, F, A, G, B...	INOSINIC ACID	non-polymer		348.2	8	Chemie (IMP)
5	D, E, F, A, G...	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	8	Chemie (ATP)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 509 (UniProt: P20839)

PDB	External Database	Details
Thr 510	-	expression tag
Phe 511	-	expression tag
Leu 512	-	expression tag
Pro 513	-	expression tag
Phe 514	-	expression tag
Thr 515	-	expression tag
Lys 516	-	expression tag
Ser 517	-	expression tag
Gly 518	-	expression tag
Cys 519	-	expression tag
Thr 520	-	expression tag
Glu 521	-	expression tag
Asp 522	-	expression tag
Ser 523	-	expression tag
Gly 524	-	expression tag
Gly 525	-	expression tag
Gly 526	-	expression tag
Arg 527	-	expression tag
Gly 528	-	expression tag
Gly 529	-	expression tag
Gly 530	-	expression tag
Gly 531	-	expression tag
Asp 532	-	expression tag
Ala 533	-	expression tag
Pro 534	-	expression tag
Gln 535	-	expression tag
Cys 536	-	expression tag
Pro 537	-	expression tag
Leu 538	-	expression tag
Leu 539	-	expression tag
Gly 540	-	expression tag
Thr 541	-	expression tag
Ala 542	-	expression tag
Ser 543	-	expression tag
Leu 544	-	expression tag
His 545	-	expression tag
Asn 546	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	466966.2
Non-Polymers*	Number of molecules	40
	Total formula weight	20521.4
All*	Total formula weight	487487.5

*Water molecules are not included.