7RGP
cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-3,Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 373 | 43385.2 | 1 | UniProt (P08754) UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | G(i) alpha-3,Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | E | Single-chain variable fragment 16 | polymer | 297 | 31870.6 | 1 | Mus musculus | ||
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | N | nanobody 35 | polymer | 160 | 17352.5 | 1 | Lama glama | ||
6 | P | Tirzepatide | polymer | 39 | 4072.5 | 1 | Homo sapiens | ||
7 | R | Glucagon-like peptide 1 receptor | polymer | 445 | 51233.1 | 1 | UniProt (P43220) Pfam (PF02793) Pfam (PF00002) In PDB | Homo sapiens (human) | GLP-1R |
Sequence modifications
A: 8 - 25 (UniProt: P08754)
A: 26 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
R: 24 - 422 (UniProt: P43220)
A: 26 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Met -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -22 | - | initiating methionine |
Lys -21 | - | expression tag |
Thr -20 | - | expression tag |
Ile -19 | - | expression tag |
Ile -18 | - | expression tag |
Ala -17 | - | expression tag |
Leu -16 | - | expression tag |
Ser -15 | - | expression tag |
Tyr -14 | - | expression tag |
Ile -13 | - | expression tag |
Phe -12 | - | expression tag |
Cys -11 | - | expression tag |
Leu -10 | - | expression tag |
Val -9 | - | expression tag |
Phe -8 | - | expression tag |
Ala -7 | - | expression tag |
Asp -6 | - | expression tag |
Tyr -5 | - | expression tag |
Lys -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Asp 0 | - | expression tag |
Ala 1 | - | expression tag |
Ala 2 | - | expression tag |
Ala 3 | - | expression tag |
Gly 4 | - | expression tag |
Gly 5 | - | expression tag |
Ser 6 | - | expression tag |
Gly 7 | - | expression tag |
Gly 8 | - | expression tag |
Ser 9 | - | expression tag |
Leu 10 | - | expression tag |
Glu 11 | - | expression tag |
Val 12 | - | expression tag |
Leu 13 | - | expression tag |
Phe 14 | - | expression tag |
Gln 15 | - | expression tag |
Gly 16 | - | expression tag |
Pro 17 | - | expression tag |
Gly 18 | - | expression tag |
Gly 19 | - | expression tag |
Ser 20 | - | expression tag |
Gly 21 | - | expression tag |
Gly 22 | - | expression tag |
Ser 23 | - | expression tag |
Phe 260 | Leu 260 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 194309.2 | |
All* | Total formula weight | 194309.2 |