7RGO

DfrA5 complexed with NADPH and 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Dihydrofolate reductase type 5	polymer	157	17547.0	2	UniProt (P11731) Pfam (PF00186) In PDB	Escherichia coli	Dihydrofolate reductase type V
2	A, B	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	A, B	4'-chloro-3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl][1,1'-biphenyl]-4-carboxamide	non-polymer		419.9	2	Chemie (4SI)
5	B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6		water	water		18.0	128	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35094.0
Non-Polymers*	Number of molecules	7
	Total formula weight	2610.8
All*	Total formula weight	37704.9

*Water molecules are not included.