7REB
E. coli dihydrofolate reductase complexed with 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 161 | 18262.6 | 1 | UniProt (C3TR70) Pfam (PF00186) UniProt (by SIFTS) (P0ABQ4) | Escherichia coli | |
| 2 | B, C, D, E, F... (A) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 3 | I (A) | 5-[(3R)-3-{7-[4-(aminomethyl)phenyl]-2H-1,3-benzodioxol-5-yl}but-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | non-polymer | 415.5 | 1 | Chemie (560) | |||
| 4 | J (A) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A: 1 - 159 (UniProt: C3TR70)
| PDB | External Database | Details |
|---|---|---|
| Asp 37 | Asn 37 | conflict |
| Leu 160 | - | expression tag |
| Glu 161 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18262.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1087.9 | |
| All* | Total formula weight | 19350.5 |
