7RCI
Crystal Structure of a PMS2 VUS with Substrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mismatch repair endonuclease PMS2 | polymer | 365 | 40486.2 | 2 | UniProt (P54278) Pfam (PF13589) Pfam (PF01119) | Homo sapiens (Human) | DNA mismatch repair protein PMS2,PMS1 protein homolog 2 |
| 2 | C, E (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | D, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 262 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 365 (UniProt: P54278)
| PDB | External Database | Details |
|---|---|---|
| Ser 335 | Asn 335 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80972.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1063.0 | |
| All* | Total formula weight | 82035.4 |
