7RBR
The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with a Lys48-linked di-ubiquitin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Papain-like protease | polymer | 318 | 35927.7 | 1 | UniProt (P0DTC1) Pfam (PF08715) UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | Non-structural protein 3, nsp3, PL2-PRO, Papain-like proteinase, PL-PRO |
| 2 | B (B) | Ubiquitin | polymer | 77 | 8691.9 | 1 | UniProt (P0CG47) Pfam (PF00240) | Homo sapiens (Human) | |
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 1 - 315 (UniProt: P0DTC1)
B: 1 - 77 (UniProt: P0CG47)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ser 111 | Cys 1674 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 77 | Met 77 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44619.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 260.5 | |
| All* | Total formula weight | 44880.1 |
