7RAM

Cryo-EM Structure of the HCMV gHgLgO Trimer Derived from AD169 and TR strains in complex with PDGFRalpha

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Envelope glycoprotein H	polymer	706	80435.4	1	UniProt (P12824) Pfam (PF02489) Pfam (PF17488) In PDB	Human herpesvirus 5 strain AD169	gH
2	B	Envelope glycoprotein L	polymer	242	27138.0	1	UniProt (P16832) Pfam (PF01801) In PDB	Human herpesvirus 5 strain AD169	gL
3	C	Envelope glycoprotein O	polymer	463	53937.7	1	UniProt (Q8AZ32) Pfam (PF07982) In PDB	Human betaherpesvirus 5	Glycoprotein O,UL74,UL74 protein
4	D	Platelet-derived growth factor receptor alpha	polymer	530	59370.0	1	UniProt (P16234) Pfam (PF07679) In PDB	Homo sapiens (human)	PDGF-R-alpha,PDGFR-alpha,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140a antigen,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor 2,PDGFR-2

Sequence modifications

A: 41 - 718 (UniProt: P12824)

PDB	External Database	Details
Gly 719	-	expression tag
Ser 720	-	expression tag
Leu 721	-	expression tag
Val 722	-	expression tag
Pro 723	-	expression tag
Arg 724	-	expression tag
Gly 725	-	expression tag
Ser 726	-	expression tag
Ser 727	-	expression tag
Ala 728	-	expression tag
Trp 729	-	expression tag
Ser 730	-	expression tag
His 731	-	expression tag
Pro 732	-	expression tag
Gln 733	-	expression tag
Phe 734	-	expression tag
Glu 735	-	expression tag
Lys 736	-	expression tag
Ala 737	-	expression tag
Gly 738	-	expression tag
His 739	-	expression tag
His 740	-	expression tag
His 741	-	expression tag
His 742	-	expression tag
His 743	-	expression tag
His 744	-	expression tag
His 745	-	expression tag
His 746	-	expression tag

D: 1 - 524 (UniProt: P16234)

PDB	External Database	Details
Pro 478	Ser 478	variant
Glu 525	-	expression tag
Asn 526	-	expression tag
Leu 527	-	expression tag
Tyr 528	-	expression tag
Phe 529	-	expression tag
Gln 530	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	220881.2
All*	Total formula weight	220881.2

*Water molecules are not included.