7RA9

Designed StabIL-2 seq1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-2	polymer	132	15133.5	1	UniProt (P60568) Pfam (PF00715)	Homo sapiens (Human)	IL-2,T-cell growth factor,TCGF
2	B, C, D (A)	PHOSPHATE ION	non-polymer		95.0	3	Chemie (PO4)
3	E (A)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
4	F (A)	water	water		18.0	34	Chemie (HOH)

Sequence modifications

A: 5 - 135 (UniProt: P60568)

PDB	External Database	Details
Met 4	-	initiating methionine
Met 31	Gly 47	engineered mutation
Leu 32	Ile 48	engineered mutation
Asp 36	Lys 52	engineered mutation
Leu 43	Met 59	engineered mutation
Ser 56	Glu 72	engineered mutation
Ala 73	Val 89	engineered mutation
Ala 76	Leu 92	engineered mutation
Gly 78	Gln 94	engineered mutation
Asp 79	Ser 95	engineered mutation
Asp 80	Lys 96	engineered mutation
Pro 81	Asn 97	engineered mutation
Lys 82	Phe 98	engineered mutation
Thr 83	His 99	engineered mutation
Ile 84	Leu 100	engineered mutation
-	Arg 101	deletion
-	Pro 102	deletion
Val 87	Leu 105	engineered mutation
Val 88	Ile 106	engineered mutation
Phe 94	Ile 112	engineered mutation
Ile 117	Val 135	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	15133.5
Non-Polymers*	Number of molecules	4
	Total formula weight	523.2
All*	Total formula weight	15656.7

*Water molecules are not included.