7R9Y
Structure of PIK3CA with covalent inhibitor 22
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 948 | 110199.4 | 1 | UniProt (P42336) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (Human) | PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA |
| 2 | B (A) | N-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-N-methyl-1-(prop-2-enoyl)piperidine-4-carboxamide | non-polymer | 629.7 | 1 | Chemie (2IX) |
Sequence modifications
A: 105 - 1048 (UniProt: P42336)
| PDB | External Database | Details |
|---|---|---|
| Ala 101 | - | expression tag |
| Gly 102 | - | expression tag |
| Thr 103 | - | expression tag |
| Met 104 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 110199.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 629.7 | |
| All* | Total formula weight | 110829.1 |
