7R7R
Structure of Human Anaplastic Lymphoma Kinase Domain in complex with ((2~{R})-2-[5-[6-amino-5-[(1~{R})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3-pyridyl]-4-methyl-thiazol-2-yl]propane-1,2-diol)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK tyrosine kinase receptor | polymer | 327 | 36909.4 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (Human) | Anaplastic lymphoma kinase |
| 2 | B (A) | (2R)-2-[5-(6-amino-5-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol | non-polymer | 472.5 | 1 | Chemie (AWJ) | |||
| 3 | C (A) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A: 1093 - 1411 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Met 1085 | - | expression tag |
| Ala 1086 | - | expression tag |
| His 1087 | - | expression tag |
| His 1088 | - | expression tag |
| His 1089 | - | expression tag |
| His 1090 | - | expression tag |
| His 1091 | - | expression tag |
| His 1092 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36909.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 472.5 | |
| All* | Total formula weight | 37381.9 |
