7R7L
Structure of human SHP2 in complex with compound 30
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 536 | 61491.4 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) | Homo sapiens (Human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3 |
| 2 | C, D (A, B) | 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3H)-one | non-polymer | 423.3 | 2 | Chemie (3ED) |
Sequence modifications
A, B: 1 - 530 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Ala -4 | - | expression tag |
| Met -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Ile 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 122982.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 846.7 | |
| All* | Total formula weight | 123829.5 |
