7R7D
Structure of human SHP2 in complex with compound 22
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 536 | 61491.4 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) | Homo sapiens (Human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3 |
| 2 | C, D (A, B) | 4-[6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl]-3-chloro-N-methylpyridin-2-amine | non-polymer | 372.9 | 2 | Chemie (37I) | |||
| 3 | E (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 530 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Ala -4 | - | expression tag |
| Met -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Ile 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 122982.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 939.9 | |
| All* | Total formula weight | 123922.7 |
