7R6X

SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2E12 Fab, S309 Fab, and S304 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (L)	Monoclonal antibody S304 Fab light chain	polymer	215	23369.9	1		Homo sapiens (Human)
2	B (H)	Monoclonal antibody S304 Fab heavy chain	polymer	223	23729.4	1		Homo sapiens (Human)
3	C (R)	Spike protein S1	polymer	216	24442.3	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
4	D (B)	Monoclonal antibody S309 Fab light chain	polymer	214	23204.7	1		Homo sapiens (Human)
5	E (A)	Monoclonal antibody S309 Fab heavy chain	polymer	230	24573.5	1		Homo sapiens (Human)
6	F (D)	Monoclonal antibody S2E12 Fab light chain	polymer	216	23546.1	1		Homo sapiens (Human)
7	G (C)	Monoclonal antibody S2E12 Fab heavy chain	polymer	226	24016.9	1		Homo sapiens (Human)
8	H (R)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
9	I, J (R, A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
10	K, L (H, A)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

R: 328 - 531 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 324	-	expression tag
Thr 325	-	expression tag
Gly 326	-	expression tag
Thr 327	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	166882.9
Non-Polymers*	Number of molecules	3
	Total formula weight	292.1
All*	Total formula weight	167175.0

*Water molecules are not included.