7R6W

SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2X35 Fab and S309 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Light Chain of Fab domain of monoclonal antibody S309	polymer	214	23204.7	1		Homo sapiens (Human)
2	B (A)	Heavy Chain of Fab domain of monoclonal antibody S309	polymer	230	24573.5	1		Homo sapiens (Human)
3	C (L)	Light Chain of Fab domain of monoclonal antibody S2X35	polymer	219	22944.3	1		Homo sapiens (Human)
4	D (H)	Heavy Chain of Fab domain of monoclonal antibody S2X35	polymer	231	24780.8	1		Homo sapiens (Human)
5	E (R)	Spike protein S1	polymer	216	24442.3	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
6	F (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	AA, BA, DA, EA, FA... (L, H, R, B, A)	SULFATE ION	non-polymer		96.1	23	Chemie (SO4)
8	L, M, P (B, A)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
9	CA, JA, O (H, R, A)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
10	HA, IA (R)	N-PROPANOL	non-polymer		60.1	2	Chemie (POL)
11	LA, MA, NA, OA, PA (B, A, L, H, R)	water	water		18.0	584	Chemie (HOH)

Sequence modifications

R: 328 - 531 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 324	-	expression tag
Thr 325	-	expression tag
Gly 326	-	expression tag
Thr 327	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	119945.6
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	31
	Total formula weight	2712.3
All*	Total formula weight	123082.3

*Water molecules are not included.