7R5D

PARP15 catalytic domain in complex with OUL234

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protein mono-ADP-ribosyltransferase PARP15	polymer	221	25439.5	2	UniProt (Q460N3) Pfam (PF00644)	Homo sapiens (human)	ADP-ribosyltransferase diphtheria toxin-like 7,ARTD7,B-aggressive lymphoma protein 3,Poly [ADP-ribose] polymerase 15,PARP-15
2	C (A)	6-propan-2-yl-[1,2,4]triazolo[3,4-b][1,3]benzothiazole	non-polymer		217.3	1	Chemie (I4X)
3	D (B)	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
4	E, F (A, B)	water	water		18.0	135	Chemie (HOH)

Sequence modifications

A, B: 481 - 678 (UniProt: Q460N3)

PDB	External Database	Details
Met 458	-	initiating methionine
His 459	-	expression tag
His 460	-	expression tag
His 461	-	expression tag
His 462	-	expression tag
His 463	-	expression tag
His 464	-	expression tag
Ser 465	-	expression tag
Ser 466	-	expression tag
Gly 467	-	expression tag
Val 468	-	expression tag
Asp 469	-	expression tag
Leu 470	-	expression tag
Gly 471	-	expression tag
Thr 472	-	expression tag
Glu 473	-	expression tag
Asn 474	-	expression tag
Leu 475	-	expression tag
Tyr 476	-	expression tag
Phe 477	-	expression tag
Gln 478	-	expression tag
Ser 479	-	expression tag
Met 480	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50878.9
Non-Polymers*	Number of molecules	2
	Total formula weight	295.4
All*	Total formula weight	51174.3

*Water molecules are not included.