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7R5B

Crystal structure of BRD4(1) in complex with the inhibitor MPM2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ABromodomain-containing protein 4polymer12715099.41UniProt (O60885)
Pfam (PF00439)
In PDB
Homo sapiens (human)Protein HUNK1
2A1-(3-aminophenyl)-3-methyl-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrol-4-onenon-polymer254.31Chemie (I5K)
3A(R,R)-2,3-BUTANEDIOLnon-polymer90.11Chemie (BU3)
4ADIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
5AHEXAETHYLENE GLYCOLnon-polymer282.31Chemie (P6G)
6waterwater18.0109Chemie (HOH)
Sequence modifications
A: 44 - 168 (UniProt: O60885)
PDBExternal DatabaseDetails
Ser 42-expression tag
Met 43-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight15099.4
Non-Polymers*Number of molecules4
Total formula weight704.9
All*Total formula weight15804.3
*Water molecules are not included.

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PDB entries from 2024-06-12

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