7R37

Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pyrococcus furiosus in complex with inosine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Adenosylhomocysteinase	polymer	441	49620.3	2	UniProt (P50251) Pfam (PF05221) Pfam (PF00670)	Pyrococcus furiosus	S-adenosyl-L-homocysteine hydrolase,AdoHcyase
2	C, E (A, B)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	2	Chemie (NAD)
3	D, F (A, B)	INOSINE	non-polymer		268.2	2	Chemie (NOS)
4	G, H (A, B)	water	water		18.0	113	Chemie (HOH)

Sequence modifications

A, B: 1 - 421 (UniProt: P50251)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	99240.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1863.3
All*	Total formula weight	101103.8

*Water molecules are not included.