7R23

Crystal structure of human Arc CTD in complex with two anti-Arc nanobodies

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ARC	polymer	181	21743.4	1	UniProt (A0A3L7I2Q1) Pfam (PF21395) Pfam (PF18162) UniProt (by SIFTS) (Q7LC44) In PDB	Homo sapiens (human)
2	B	Chains: B	polymer	128	14078.6	1		Vicugna pacos
3	C	Chains: C	polymer	120	13127.6	1		Vicugna pacos

Sequence modifications

A: 206 - 361 (UniProt: A0A3L7I2Q1)

PDB	External Database	Details
Met 181	-	initiating methionine
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
Leu 188	-	expression tag
Glu 189	-	expression tag
Ser 190	-	expression tag
Thr 191	-	expression tag
Ser 192	-	expression tag
Leu 193	-	expression tag
Tyr 194	-	expression tag
Lys 195	-	expression tag
Lys 196	-	expression tag
Ala 197	-	expression tag
Gly 198	-	expression tag
Ser 199	-	expression tag
Glu 200	-	expression tag
Asn 201	-	expression tag
Leu 202	-	expression tag
Tyr 203	-	expression tag
Phe 204	-	expression tag
Gln 205	-	expression tag
Asp 317	Glu 454	conflict
Asp 358	Gly 495	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	48949.6
All*	Total formula weight	48949.6

*Water molecules are not included.