7R1U
Crystal structure of SARS-CoV-2 nsp10/nsp16 in complex with the WZ16 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 2'-O-methyltransferase nsp16 | polymer | 299 | 33486.4 | 1 | UniProt (P0DTD1) Pfam (PF06460) | Severe acute respiratory syndrome coronavirus 2 | Non-structural protein 16,nsp16 |
| 2 | B (B) | Non-structural protein 10 | polymer | 123 | 13126.1 | 1 | UniProt (P0DTD1) Pfam (PF09401) | Severe acute respiratory syndrome coronavirus 2 | nsp10,Growth factor-like peptide,GFL |
| 3 | C (A) | (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid | non-polymer | 395.4 | 1 | Chemie (4IK) | |||
| 4 | D (A) | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE | non-polymer | 787.4 | 1 | Chemie (GTA) | |||
| 5 | E (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 6 | F, G (B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | H, I (A, B) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P0DTD1)
B: 10 - 131 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 9 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46612.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1508.9 | |
| All* | Total formula weight | 48121.4 |
