7QQ7
Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with an inhibitor at partial occupancy with PEG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Steroid C26-monooxygenase | polymer | 398 | 44371.2 | 1 | UniProt (P9WPL5) Pfam (PF00067) In PDB | Mycobacterium tuberculosis H37Rv | Cholest-4-en-3-one C26-monooxygenase,Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming],Cholesterol C26-monooxygenase,Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming],Cytochrome P450 142,Steroid C27-monooxygenase |
| 2 | A | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 5 | A | BROMIDE ION | non-polymer | 79.9 | 3 | Chemie (BR) | |||
| 6 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 7 | A | ~{N}-[4-(pyridin-4-ylmethyl)phenyl]benzenesulfonamide | non-polymer | 324.4 | 1 | Chemie (EIQ) | |||
| 8 | water | water | 18.0 | 464 | Chemie (HOH) |
Sequence modifications
A: 2 - 398 (UniProt: P9WPL5)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44371.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1504.8 | |
| All* | Total formula weight | 45876.0 |
