7QQ6

GCN2 (EIF2ALPHA KINASE 4, E2AK4) IN COMPLEX WITH COMPOUND 1 (dovitinib)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	eIF-2-alpha kinase GCN2	polymer	320	36784.6	4	UniProt (Q9P2K8) Pfam (PF00069)	Homo sapiens (human)	Eukaryotic translation initiation factor 2-alpha kinase 4,GCN2-like protein
2	E, F, G, H (A, B, C, D)	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one	non-polymer		392.4	4	Chemie (38O)
3	I, J, K, L (A, B, C, D)	water	water		18.0	45	Chemie (HOH)

Sequence modifications

A, B, C, D: 577 - 1020 (UniProt: Q9P2K8)

PDB	External Database	Details
Gly 575	-	expression tag
Ser 576	-	expression tag
-	Pro 662	deletion
-	Ala 663	deletion
-	Gly 664	deletion
-	Pro 665	deletion
-	Gly 666	deletion
-	Thr 667	deletion
-	Pro 668	deletion
-	Pro 669	deletion
-	Pro 670	deletion
-	Asp 671	deletion
-	Ser 672	deletion
-	Gly 673	deletion
-	Pro 674	deletion
-	Leu 675	deletion
-	Ala 676	deletion
-	Lys 677	deletion
-	Asp 678	deletion
-	Asp 679	deletion
-	Arg 680	deletion
-	Ala 681	deletion
-	Ala 682	deletion
-	Arg 683	deletion
-	Gly 684	deletion
-	Gln 685	deletion
-	Pro 686	deletion
-	Ala 687	deletion
-	Ser 688	deletion
-	Asp 689	deletion
-	Thr 690	deletion
-	Asp 691	deletion
-	Gly 692	deletion
-	Leu 693	deletion
-	Asp 694	deletion
-	Ser 695	deletion
-	Val 696	deletion
-	Glu 697	deletion
-	Ala 698	deletion
-	Ala 699	deletion
-	Ala 700	deletion
-	Pro 701	deletion
-	Pro 702	deletion
-	Pro 703	deletion
-	Ile 704	deletion
-	Leu 705	deletion
-	Ser 706	deletion
-	Ser 707	deletion
-	Ser 708	deletion
-	Val 709	deletion
-	Glu 710	deletion
-	Trp 711	deletion
-	Ser 712	deletion
-	Thr 713	deletion
-	Ser 714	deletion
-	Gly 715	deletion
-	Glu 716	deletion
-	Arg 717	deletion
-	Ser 718	deletion
-	Ala 719	deletion
-	Ser 720	deletion
-	Ala 721	deletion
-	Arg 722	deletion
-	Phe 723	deletion
-	Pro 724	deletion
-	Ala 725	deletion
-	Thr 726	deletion
-	Gly 727	deletion
-	Pro 728	deletion
-	Gly 729	deletion
-	Ser 730	deletion
-	Ser 731	deletion
-	Asp 732	deletion
-	Asp 733	deletion
-	Glu 734	deletion
-	Asp 735	deletion
-	Asp 736	deletion
-	Asp 737	deletion
-	Glu 738	deletion
-	Asp 739	deletion
-	Glu 740	deletion
-	His 741	deletion
-	Gly 742	deletion
-	Gly 743	deletion
-	Val 744	deletion
-	Phe 745	deletion
-	Ser 746	deletion
-	Gln 747	deletion
-	Ser 748	deletion
-	Phe 749	deletion
-	Leu 750	deletion
-	Pro 751	deletion
-	Ala 752	deletion
-	Ser 753	deletion
-	Asp 754	deletion
-	Ser 755	deletion
-	Glu 756	deletion
-	Ser 757	deletion
-	Asp 758	deletion
-	Ile 759	deletion
-	Ile 760	deletion
-	Phe 761	deletion
-	Asp 762	deletion
-	Asn 763	deletion
-	Glu 764	deletion
-	Asp 765	deletion
-	Glu 766	deletion
-	Asn 767	deletion
-	Ser 768	deletion
-	Lys 769	deletion
-	Ser 770	deletion
-	Gln 771	deletion
-	Asn 772	deletion
-	Gln 773	deletion
-	Asp 774	deletion
-	Glu 775	deletion
-	Asp 776	deletion
-	Cys 777	deletion
-	Asn 778	deletion
-	Glu 779	deletion
-	Lys 780	deletion
-	Asn 781	deletion
-	Gly 782	deletion
-	Cys 783	deletion
-	His 784	deletion
-	Glu 785	deletion
-	Ser 786	deletion
-	Glu 787	deletion
Asn 848	Asp 848	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	147138.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1569.7
All*	Total formula weight	148708.3

*Water molecules are not included.