7QQ3
Cryo-EM structure of the E.coli 50S ribosomal subunit in complex with the antibiotic Myxovalargin A.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | I | 23S ribosomal RNA | polymer | 2904 | 941752.6 | 1 | GenBank (939732440) | Escherichia coli K-12 | |
| 2 | J | 5S ribosomal RNA | polymer | 120 | 38815.1 | 1 | GenBank (1526269268) | Escherichia coli K-12 | |
| 3 | K | 50S ribosomal protein L2 | polymer | 273 | 29923.6 | 1 | UniProt (P60422) Pfam (PF00181) Pfam (PF03947) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL2 |
| 4 | L | 50S ribosomal protein L3 | polymer | 209 | 22277.5 | 1 | UniProt (P60438) Pfam (PF00297) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL3 |
| 5 | M | 50S ribosomal protein L4 | polymer | 201 | 22121.6 | 1 | UniProt (P60723) Pfam (PF00573) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL4 |
| 6 | O | 50S ribosomal protein L6 | polymer | 177 | 18932.8 | 1 | UniProt (P0AG55) Pfam (PF00347) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL6 |
| 7 | R | 50S ribosomal protein L13 | polymer | 142 | 16050.6 | 1 | UniProt (P0AA10) Pfam (PF00572) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL13 |
| 8 | S | 50S ribosomal protein L14 | polymer | 123 | 13565.1 | 1 | UniProt (P0ADY3) Pfam (PF00238) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL14 |
| 9 | T | 50S ribosomal protein L15 | polymer | 143 | 14879.4 | 1 | UniProt (P02413) Pfam (PF00828) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL15 |
| 10 | U | 50S ribosomal protein L16 | polymer | 136 | 15312.3 | 1 | UniProt (P0ADY7) Pfam (PF00252) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL16 |
| 11 | V | 50S ribosomal protein L17 | polymer | 127 | 14393.7 | 1 | UniProt (P0AG44) Pfam (PF01196) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL17 |
| 12 | W | 50S ribosomal protein L18 | polymer | 117 | 12794.7 | 1 | UniProt (P0C018) Pfam (PF00861) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL18 |
| 13 | X | 50S ribosomal protein L19 | polymer | 115 | 13159.3 | 1 | UniProt (P0A7K6) Pfam (PF01245) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL19 |
| 14 | Y | 50S ribosomal protein L20 | polymer | 118 | 13528.0 | 1 | UniProt (P0A7L3) Pfam (PF00453) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL20 |
| 15 | Z | 50S ribosomal protein L21 | polymer | 103 | 11586.4 | 1 | UniProt (P0AG48) Pfam (PF00829) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL21 |
| 16 | a | 50S ribosomal protein L22 | polymer | 110 | 12253.4 | 1 | UniProt (P61175) Pfam (PF00237) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL22 |
| 17 | b | 50S ribosomal protein L23 | polymer | 100 | 11222.2 | 1 | UniProt (P0ADZ0) Pfam (PF00276) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL23 |
| 18 | c | 50S ribosomal protein L24 | polymer | 104 | 11339.3 | 1 | UniProt (P60624) Pfam (PF00467) Pfam (PF17136) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL24 |
| 19 | d | 50S ribosomal protein L25 | polymer | 94 | 10713.5 | 1 | UniProt (P68919) Pfam (PF01386) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL25 |
| 20 | e | 50S ribosomal protein L27 | polymer | 85 | 9146.5 | 1 | UniProt (P0A7L8) Pfam (PF01016) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL27 |
| 21 | f | 50S ribosomal protein L28 | polymer | 78 | 9027.6 | 1 | UniProt (P0A7M2) Pfam (PF00830) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL28 |
| 22 | g | 50S ribosomal protein L29 | polymer | 63 | 7286.5 | 1 | UniProt (P0A7M6) Pfam (PF00831) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL29 |
| 23 | h | 50S ribosomal protein L30 | polymer | 59 | 6554.8 | 1 | UniProt (P0AG51) Pfam (PF00327) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein uL30 |
| 24 | i | 50S ribosomal protein L32 | polymer | 57 | 6463.4 | 1 | UniProt (P0A7N4) Pfam (PF01783) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL32 |
| 25 | j | 50S ribosomal protein L33 | polymer | 55 | 6388.6 | 1 | UniProt (P0A7N9) Pfam (PF00471) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL33 |
| 26 | k | 50S ribosomal protein L34 | polymer | 46 | 5397.5 | 1 | UniProt (P0A7P5) Pfam (PF00468) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL34 |
| 27 | l | 50S ribosomal protein L35 | polymer | 65 | 7313.0 | 1 | UniProt (P0A7Q1) Pfam (PF01632) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL35,Ribosomal protein A |
| 28 | m | 50S ribosomal protein L36 | polymer | 38 | 4377.4 | 1 | UniProt (P0A7Q6) Pfam (PF00444) In PDB | Escherichia coli K-12 | Large ribosomal subunit protein bL36-A,Ribosomal protein B |
| 29 | B | Myxovalargin A | polymer | 16 | 1678.1 | 1 | BIRD (PRD_002442) | Myxococcus fulvus | |
| 30 | I, J, L | MAGNESIUM ION | non-polymer | 24.3 | 145 | Chemie (MG) | |||
| 31 | m | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 32 | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 29 |
| Total formula weight | 1308254.1 | |
| Non-Polymers* | Number of molecules | 146 |
| Total formula weight | 3589.6 | |
| All* | Total formula weight | 1311843.8 |
